Rotavirus NSP4 Triggers Secretion of Proinflammatory Cytokines from Macrophages via Toll-Like Receptor 2

Nonstructural protein 4 (NSP4), encoded by rotavirus, exhibits various properties linked to viral pathogenesis, including enterotoxic activity. A recent study (O. V. Kavanagh et al., Vaccine 28:3106-3111, 2010) indicated that NSP4 also has adjuvant properties, suggesting a possible role in the innat...

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Detalhes bibliográficos
Main Authors: Ge, Yi, Mansell, Ashley, Ussher, James E., Brooks, Anna E. S., Manning, Kristy, Wang, Carol J. H., Taylor, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807279/
https://ncbi.nlm.nih.gov/pubmed/23926349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03099-12
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