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Mismatch repair, but not heteroduplex rejection, is temporally coupled to DNA replication

In eukaryotes, it is unknown if mismatch repair (MMR) is temporally coupled to DNA replication and how strand-specific MMR is directed. Here we fused Saccharomyces cerevisiae MSH6 with cyclins to restrict the availability of the Msh2-Msh6 mismatch recognition complex to either S-phase or G2/M. The M...

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Bibliographische Detailangaben
Hauptverfasser: Hombauer, Hans, Srivatsan, Anjana, Putnam, Christopher D., Kolodner, Richard D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806717/
https://ncbi.nlm.nih.gov/pubmed/22194578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1210770
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