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Visualization of Eukaryotic DNA Mismatch Repair Reveals Distinct Recognition and Repair Intermediates

DNA Mismatch Repair (MMR) increases replication fidelity by eliminating mispaired bases resulting from replication errors. In Saccharomyces cerevisiae mispairs are primarily detected by the Msh2-Msh6 complex and corrected following subsequent recruitment of the Mlh1-Pms1 complex. Here, we visualized...

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Detalhes bibliográficos
Main Authors: Hombauer, Hans, Campbell, Christopher S., Smith, Catherine E., Desai, Arshad, Kolodner, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478091/
https://ncbi.nlm.nih.gov/pubmed/22118461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.10.025
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