VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

In proliferative diabetic retinopathy (PDR), retinal ischemia promotes neovascularization (NV), which can lead to profound vision loss in diabetic patients. Treatment for PDR, panretinal photocoagulation, is inherently destructive and has significant visual consequences. Therapies targeting vascular...

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Bibliografski detalji
Glavni autori: Rodrigues, Murilo, Xin, Xiaoban, Jee, Kathleen, Babapoor-Farrokhran, Savalan, Kashiwabuchi, Fabiana, Ma, Tao, Bhutto, Imran, Hassan, Syed Junaid, Daoud, Yassine, Baranano, David, Solomon, Sharon, Lutty, Gerard, Semenza, Gregg L., Montaner, Silvia, Sodhi, Akrit
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2013
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806594/
https://ncbi.nlm.nih.gov/pubmed/23884892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0014
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