VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

In proliferative diabetic retinopathy (PDR), retinal ischemia promotes neovascularization (NV), which can lead to profound vision loss in diabetic patients. Treatment for PDR, panretinal photocoagulation, is inherently destructive and has significant visual consequences. Therapies targeting vascular...

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Main Authors: Rodrigues, Murilo, Xin, Xiaoban, Jee, Kathleen, Babapoor-Farrokhran, Savalan, Kashiwabuchi, Fabiana, Ma, Tao, Bhutto, Imran, Hassan, Syed Junaid, Daoud, Yassine, Baranano, David, Solomon, Sharon, Lutty, Gerard, Semenza, Gregg L., Montaner, Silvia, Sodhi, Akrit
格式: Artigo
語言:Inglês
出版: American Diabetes Association 2013
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806594/
https://ncbi.nlm.nih.gov/pubmed/23884892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0014
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