VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy

In proliferative diabetic retinopathy (PDR), retinal ischemia promotes neovascularization (NV), which can lead to profound vision loss in diabetic patients. Treatment for PDR, panretinal photocoagulation, is inherently destructive and has significant visual consequences. Therapies targeting vascular...

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Bibliografiska uppgifter
Huvudupphovsmän: Rodrigues, Murilo, Xin, Xiaoban, Jee, Kathleen, Babapoor-Farrokhran, Savalan, Kashiwabuchi, Fabiana, Ma, Tao, Bhutto, Imran, Hassan, Syed Junaid, Daoud, Yassine, Baranano, David, Solomon, Sharon, Lutty, Gerard, Semenza, Gregg L., Montaner, Silvia, Sodhi, Akrit
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Diabetes Association 2013
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806594/
https://ncbi.nlm.nih.gov/pubmed/23884892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0014
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