Inactivation of tumor-specific CD8(+) CTLs by tumor-infiltrating tolerogenic dendritic cells

Cancer immunosurveillance failure is largely attributed to the insufficient activation of tumor-specific class I major histocompatibility complex (MHC) molecule (MHC-I)-restricted CD8(+) cytotoxic T lymphocytes (CTLs). DEC-205(+) dendritic cells (DCs), having the ability to cross-present, can presen...

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Bibliographic Details
Main Authors: Harimoto, Hirotomo, Shimizu, Masumi, Nakagawa, Yohko, Nakatsuka, Katsuhisa, Wakabayashi, Ayako, Sakamoto, Choitsu, Takahashi, Hidemi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3806489/
https://ncbi.nlm.nih.gov/pubmed/24018532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2013.38
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