HMGB1 released from intestinal epithelia damaged by cholera toxin adjuvant contributes to activation of mucosal dendritic cells and induction of intestinal cytotoxic T lymphocytes and IgA

Cholera toxin (CT) is a potent mucosal adjuvant and oral administration of ovalbumin (OVA) antigens plus CT induces OVA-specific CD8(+) cytotoxic T lymphocytes (CTLs) and IgA production in intestinal mucosa. However, the mechanisms of induction of these immune responses remain unknown. Intestinal OV...

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Vydáno v:Cell Death Dis
Hlavní autoři: Wakabayashi, Ayako, Shimizu, Masumi, Shinya, Eiji, Takahashi, Hidemi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967345/
https://ncbi.nlm.nih.gov/pubmed/29795370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0665-z
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