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Infiltrating CTLs are bothered by HLA-E on tumors

We recently described the upregulation of HLA-E in ovarian and cervical cancers. Instead of interacting with natural killer cells, HLA-E appeared to inhibit intratumoral cytotoxic T lymphocytes (CTL) via the receptor CD94/NKG2A. Strikingly, the survival benefit of intraepithelial infiltrating CTL wa...

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Bibliografiska uppgifter
Huvudupphovsmän: Gooden, Marloes J.M., van Hall, Thorbald
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376958/
https://ncbi.nlm.nih.gov/pubmed/22720221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.1.1.17961
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