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A Novel Somatic Mouse Model to Survey Tumorigenic Potential Applied to the Hedgehog Pathway
We report a novel mouse model for the generation of sporadic tumors and show the efficiency of this approach by surveying Hedgehog (Hh)–related tumors. Up-regulation of the Hh pathway is achieved by conditionally regulated expression of an activated allele of Smoothened (R26-SmoM2) using either spor...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3806052/ https://ncbi.nlm.nih.gov/pubmed/17047082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-0657 |
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