Mutations in Hedgehog pathway genes in fetal rhabdomyomas

Ligand-independent, constitutive activation of Hedgehog signalling in mice expressing a mutant, activated SmoM2 allele results in the development of multifocal, highly differentiated tumours that express myogenic markers (including desmin, actin, MyoD and myogenin). The histopathology of these tumou...

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Autors principals: Hettmer, Simone, Teot, Lisa A, van Hummelen, Paul, MacConaill, Laura, Bronson, Roderick T, Dall’Osso, Claudia, Mao, Junhao, McMahon, Andrew P, Gruber, Peter J, Grier, Holcombe E, Rodriguez-Galindo, Carlos, Fletcher, Christopher D, Wagers, Amy J
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875333/
https://ncbi.nlm.nih.gov/pubmed/23780909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4229
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