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Myogenic tumors in Nevoid Basal Cell Carcinoma syndrome

In mice, activated Hedgehog (Hh) signaling induces tumors with myogenic differentiation. In humans, hyperactive Hh signaling due to germline PTCH1 mutations has been linked to Nevoid Basal Cell Carcinoma syndrome (NBCCS). We report an embryonal rhabdomyosarcoma in a 16-months old girl with NBCCS and...

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Detalhes bibliográficos
Main Authors: Hettmer, Simone, Teot, Lisa A., Kozakewich, Harry, Werger, Annette M., Davies, Kimberly J., Fletcher, Christopher D. M., Grier, Holcombe E., Rodriguez-Galindo, Carlos, Wagers, Amy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127382/
https://ncbi.nlm.nih.gov/pubmed/24517962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPH.0000000000000115
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