Development of Inducible Leucine-rich Repeat Kinase 2 (LRRK2) Cell Lines for Therapeutics Development in Parkinson’s Disease

The pathogenic mechanism(s) contributing to loss of dopamine neurons in Parkinson’s disease (PD) remain obscure. Leucine-rich repeat kinase 2 (LRRK2) mutations are linked, as a causative gene, to PD. LRRK2 mutations are estimated to account for 10 % of familial and between 1 % and 3 % of sporadic PD...

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Hlavní autoři: Huang, Liang, Shimoji, Mika, Wang, Juan, Shah, Salim, Kamila, Sukanta, Biehl, Edward R., Lim, Seung, Chang, Allison, Maguire-Zeiss, Kathleen A., Su, Xiaomin, Federoff, Howard J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2013
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805857/
https://ncbi.nlm.nih.gov/pubmed/23963789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-013-0208-3
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