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Differential Effects of Genistein on Prostate Cancer Cells Depend on Mutational Status of the Androgen Receptor

Blocking the androgen receptor (AR) activity is the main goal of therapies for advanced prostate cancer (PCa). However, relapse with a more aggressive, hormone refractory PCa arises, which harbors restored AR activity. One mechanism of such reactivation occurs through acquisition of AR mutations tha...

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Bibliografiske detaljer
Main Authors: Mahmoud, Abeer M., Zhu, Tian, Parray, Aijaz, Siddique, Hifzur R., Yang, Wancai, Saleem, Mohammad, Bosland, Maarten C.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805529/
https://ncbi.nlm.nih.gov/pubmed/24167630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078479
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