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PTEN Germline Mutations in Patients Initially Tested for Other Hereditary Cancer Syndromes: Would Use of Risk Assessment Tools Reduce Genetic Testing?

PURPOSE. PTEN Hamartoma Tumor syndrome (PHTS) includes patients with Cowden syndrome or other syndromes with germline mutation of the PTEN tumor suppressor gene. The risk for breast, colorectal, and endometrial cancer and polyposis is increased, creating clinical overlap with hereditary breast and o...

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Detalhes bibliográficos
Main Authors: Mester, Jessica L., Moore, Rebekah A., Eng, Charis
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805149/
https://ncbi.nlm.nih.gov/pubmed/24037976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2013-0174
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