Diterpene Cyclases and the Nature of the Isoprene Fold

The structures and mechanism of action of many terpene cyclases are known, but there are no structures of diterpene cyclases. Here, we propose structural models based on bioinformatics, site-directed mutagenesis, domain swapping, enzyme inhibition and spectroscopy that help explain the nature of dit...

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Main Authors: Cao, Rong, Zhang, Yonghui, Mann, Francis M., Huang, Cancan, Mukkamala, Dushyant, Hudock, Michael P., Mead, Matthew, Prisic, Sladjana, Wang, Ke, Lin, Fu-Yang, Chang, Ting-Kai, Peters, Reuben, Oldfield, Eric
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805035/
https://ncbi.nlm.nih.gov/pubmed/20602361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22751
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