Diterpene Cyclases and the Nature of the Isoprene Fold

The structures and mechanism of action of many terpene cyclases are known, but there are no structures of diterpene cyclases. Here, we propose structural models based on bioinformatics, site-directed mutagenesis, domain swapping, enzyme inhibition and spectroscopy that help explain the nature of dit...

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Hlavní autoři: Cao, Rong, Zhang, Yonghui, Mann, Francis M., Huang, Cancan, Mukkamala, Dushyant, Hudock, Michael P., Mead, Matthew, Prisic, Sladjana, Wang, Ke, Lin, Fu-Yang, Chang, Ting-Kai, Peters, Reuben, Oldfield, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805035/
https://ncbi.nlm.nih.gov/pubmed/20602361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22751
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