Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) α-chain, TRAV1-2–TRAJ33, and are activated by vitamin B metabolites bound by the major histocompatibility complex (MHC)–related class I–like molecule, MR1. Understanding MAIT cell biology has been restra...

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Main Authors: Reantragoon, Rangsima, Corbett, Alexandra J., Sakala, Isaac G., Gherardin, Nicholas A., Furness, John B., Chen, Zhenjun, Eckle, Sidonia B.G., Uldrich, Adam P., Birkinshaw, Richard W., Patel, Onisha, Kostenko, Lyudmila, Meehan, Bronwyn, Kedzierska, Katherine, Liu, Ligong, Fairlie, David P., Hansen, Ted H., Godfrey, Dale I., Rossjohn, Jamie, McCluskey, James, Kjer-Nielsen, Lars
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804952/
https://ncbi.nlm.nih.gov/pubmed/24101382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130958
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