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Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

Mucosal-associated invariant T (MAIT) cells express a semiinvariant αβ T cell receptor (TCR) that binds MHC class I–like molecule (MR1). However, the molecular basis for MAIT TCR recognition by MR1 is unknown. In this study, we present the crystal structure of a human Vα7.2Jα33-Vβ2 MAIT TCR. Mutagen...

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Bibliografski detalji
Glavni autori: Reantragoon, Rangsima, Kjer-Nielsen, Lars, Patel, Onisha, Chen, Zhenjun, Illing, Patricia T., Bhati, Mugdha, Kostenko, Lyudmila, Bharadwaj, Mandvi, Meehan, Bronwyn, Hansen, Ted H., Godfrey, Dale I., Rossjohn, Jamie, McCluskey, James
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328369/
https://ncbi.nlm.nih.gov/pubmed/22412157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112095
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