Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

Mucosal-associated invariant T (MAIT) cells express a semiinvariant αβ T cell receptor (TCR) that binds MHC class I–like molecule (MR1). However, the molecular basis for MAIT TCR recognition by MR1 is unknown. In this study, we present the crystal structure of a human Vα7.2Jα33-Vβ2 MAIT TCR. Mutagen...

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Detalhes bibliográficos
Main Authors: Reantragoon, Rangsima, Kjer-Nielsen, Lars, Patel, Onisha, Chen, Zhenjun, Illing, Patricia T., Bhati, Mugdha, Kostenko, Lyudmila, Bharadwaj, Mandvi, Meehan, Bronwyn, Hansen, Ted H., Godfrey, Dale I., Rossjohn, Jamie, McCluskey, James
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328369/
https://ncbi.nlm.nih.gov/pubmed/22412157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112095
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