Aliskiren Attenuates Steatohepatitis and Increases Turnover of Hepatic Fat in Mice Fed with a Methionine and Choline Deficient Diet

BACKGROUND & AIMS: Activation of the renin-angiotensin-system is known to play a role in nonalcoholic steatohepatitis. Renin knockout mice manifest decreased hepatic steatosis. Aliskiren is the first direct renin inhibitor to be approved for clinical use. Our study aims to evaluate the possible...

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Autores principales: Lee, Kuei-Chuan, Chan, Che-Chang, Yang, Ying-Ying, Hsieh, Yun-Cheng, Huang, Yi-Hsiang, Lin, Han-Chieh
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804600/
https://ncbi.nlm.nih.gov/pubmed/24204981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077817
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