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Aliskiren Attenuates Steatohepatitis and Increases Turnover of Hepatic Fat in Mice Fed with a Methionine and Choline Deficient Diet

BACKGROUND & AIMS: Activation of the renin-angiotensin-system is known to play a role in nonalcoholic steatohepatitis. Renin knockout mice manifest decreased hepatic steatosis. Aliskiren is the first direct renin inhibitor to be approved for clinical use. Our study aims to evaluate the possible...

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Autori principali: Lee, Kuei-Chuan, Chan, Che-Chang, Yang, Ying-Ying, Hsieh, Yun-Cheng, Huang, Yi-Hsiang, Lin, Han-Chieh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804600/
https://ncbi.nlm.nih.gov/pubmed/24204981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077817
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