Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

A “switch” from oxidative phosphorylation (OXPHOS) to aerobic glycolysis is a hallmark of T cell activation and is thought to be required to meet the metabolic demands of proliferation. However, why proliferating cells adopt this less efficient metabolism, especially in an oxygen-replete environment...

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Autori principali: Chang, Chih-Hao, Curtis, Jonathan D., Maggi, Leonard B., Faubert, Brandon, Villarino, Alejandro V., O’Sullivan, David, Huang, Stanley Ching-Cheng, van der Windt, Gerritje J.W., Blagih, Julianna, Qiu, Jing, Weber, Jason D., Pearce, Edward J., Jones, Russell G., Pearce, Erika L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804311/
https://ncbi.nlm.nih.gov/pubmed/23746840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.05.016
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