The impact of molecular manipulation in residue 114 of Human Immunodeficiency Virus Type-1 reverse transcriptase on dNTP substrate binding and viral replication

Human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) has a unique tight binding to dNTP substrates. Structural modeling of Ala-114 of HIV-1 RT suggests that longer side chains at this residue can reduce the space normally occupied by the sugar moiety of an incoming dNTP. Indeed, mu...

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Hlavní autoři: Van Cor-Hosmer, Sarah K., Daddacha, Waaqo, Kelly, Z, Tsurumi, Amy, Kennedy, Edward M., Kim, Baek
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804253/
https://ncbi.nlm.nih.gov/pubmed/22153297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.11.004
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