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Restricted 5′-End Gap Repair of HIV-1 Integration Due to Limited Cellular dNTP Concentrations in Human Primary Macrophages

HIV-1 proviral DNA integration into host chromosomal DNA is only partially completed by the viral integrase, leaving two single-stranded DNA gaps with 5′-end mismatched viral DNA flaps. It has been inferred that these gaps are repaired by the cellular DNA repair machinery. Here, we investigated the...

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Detalhes bibliográficos
Main Authors: Van Cor-Hosmer, Sarah K., Kim, Dong-Hyun, Daly, Michele B., Daddacha, Waaqo, Kim, Baek
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829171/
https://ncbi.nlm.nih.gov/pubmed/24097986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.486787
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