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A new approach to measuring protein backbone protection with high spatial resolution using H/D exchange and electron capture dissociation
Inadequate spatial resolution remains one of the most serious limitations of hydrogen/deuterium exchange mass spectrometry (HDX MS), especially when applied to larger proteins (over 30 kDa). Supplementing proteolytic fragmentation of the protein in solution with ion dissociation in the gas phase has...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3801164/ https://ncbi.nlm.nih.gov/pubmed/23978257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac401868b |
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