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Peptide transporter DtpA has two alternate conformations, one of which is promoted by inhibitor binding

Peptide transporters (PTRs) of the large PTR family facilitate the uptake of di- and tripeptides to provide cells with amino acids for protein synthesis and for metabolic intermediates. Although several PTRs have been structurally and functionally characterized, how drugs modulate peptide transport...

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Main Authors: Bippes, Christian A., Ge, Lin, Meury, Marcel, Harder, Daniel, Ucurum, Zöhre, Daniel, Hannelore, Fotiadis, Dimitrios, Müller, Daniel J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801073/
https://ncbi.nlm.nih.gov/pubmed/24082128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312959110
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