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Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair

Recruitment of DNA repair factors and modulation of chromatin structure at sites of DNA double-strand breaks (DSBs) is a complex and highly orchestrated process. We developed a system that can induce DSBs rapidly at defined endogenous sites in mammalian genomes and enables direct assessment of repai...

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Detalhes bibliográficos
Main Authors: Goldstein, Michael, Derheimer, Frederick A., Tait-Mulder, Jacqueline, Kastan, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801049/
https://ncbi.nlm.nih.gov/pubmed/24082117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306160110
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