Prostaglandin E(2) deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes

Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to nonselective cyclooxygenase (COX) inhibitors. Ex vivo studies suggest that functional abnormalities of the COX-2/microsomal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Liu, Tao, Laidlaw, Tanya M., Katz, Howard R., Boyce, Joshua A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2013
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801005/
https://ncbi.nlm.nih.gov/pubmed/24085850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313185110
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