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Prostaglandin E(2) deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes
Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to nonselective cyclooxygenase (COX) inhibitors. Ex vivo studies suggest that functional abnormalities of the COX-2/microsomal...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3801005/ https://ncbi.nlm.nih.gov/pubmed/24085850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313185110 |
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