Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA.

We have analyzed the level of intraindividual sequence variability (heteroplasmy) of mtDNA in human brain by denaturing gradient gel electrophoresis and sequencing. Single base substitutions, as well as insertions or deletions of single bases, were numerous in the noncoding control region (D-loop),...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Jazin, E E, Cavelier, L, Eriksson, I, Oreland, L, Gyllensten, U
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38000/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8901590/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.22.12382
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