The orthosteric GABA(A) receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors

BACKGROUND AND PURPOSE: Explorations into the heterogeneous population of native GABA type A receptors (GABA(A)Rs) and the physiological functions governed by the multiple GABA(A)R subtypes have for decades been hampered by the lack of subtype-selective ligands. EXPERIMENTAL APPROACH: The functional...

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Autors principals: Hoestgaard-Jensen, K, O'Connor, R M, Dalby, N O, Simonsen, C, Finger, B C, Golubeva, A, Hammer, H, Bergmann, M L, Kristiansen, U, Krogsgaard-Larsen, P, Bräuner-Osborne, H, Ebert, B, Frølund, B, Cryan, J F, Jensen, A A
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2013
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799604/
https://ncbi.nlm.nih.gov/pubmed/23957253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12340
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