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The orthosteric GABA(A) receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors
BACKGROUND AND PURPOSE: Explorations into the heterogeneous population of native GABA type A receptors (GABA(A)Rs) and the physiological functions governed by the multiple GABA(A)R subtypes have for decades been hampered by the lack of subtype-selective ligands. EXPERIMENTAL APPROACH: The functional...
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| Main Authors: | , , , , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Publishing Ltd
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3799604/ https://ncbi.nlm.nih.gov/pubmed/23957253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12340 |
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