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Real-time characterization of cannabinoid receptor 1 (CB(1)) allosteric modulators reveals novel mechanism of action
BACKGROUND AND PURPOSE: The cannabinoid receptor type 1 (CB(1)) has an allosteric binding site. The drugs ORG27569 {5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]-1H-indole-2-carboxamide} and PSNCBAM-1 {1-(4-chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea} have been extensively...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Blackwell Publishing Ltd
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3799602/ https://ncbi.nlm.nih.gov/pubmed/23937487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12329 |
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