ORM-10103, a novel specific inhibitor of the Na(+)/Ca(2+) exchanger, decreases early and delayed afterdepolarizations in the canine heart

BACKGROUND AND PURPOSE: At present there are no small molecule inhibitors that show strong selectivity for the Na(+)/Ca(2+) exchanger (NCX). Hence, we studied the electrophysiological effects of acute administration of ORM-10103, a new NCX inhibitor, on the NCX and L-type Ca(2+) currents and on the...

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Bibliographische Detailangaben
Hauptverfasser: Jost, N, Nagy, N, Corici, C, Kohajda, Z, Horváth, A, Acsai, K, Biliczki, P, Levijoki, J, Pollesello, P, Koskelainen, T, Otsomaa, L, Tóth, A, Papp, J Gy, Varró, A, Virág, L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2013
Schlagworte:
Research Paper With Commentary
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799592/
https://ncbi.nlm.nih.gov/pubmed/23647096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12228
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