Discovery and characterization of ORM‐11372, a novel inhibitor of the sodium‐calcium exchanger with positive inotropic activity

BACKGROUND AND PURPOSE: The lack of selective sodium–calcium exchanger (NCX) inhibitors has hampered the exploration of physiological and pathophysiological roles of cardiac NCX 1.1. We aimed to discover more potent and selective drug like NCX 1.1 inhibitor. EXPERIMENTAL APPROACH: A flavan series‐ba...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Otsomaa, Leena, Levijoki, Jouko, Wohlfahrt, Gerd, Chapman, Hugh, Koivisto, Ari‐Pekka, Syrjänen, Kaisa, Koskelainen, Tuula, Peltokorpi, Saara‐Elisa, Finckenberg, Piet, Heikkilä, Aira, Abi‐Gerges, Najah, Ghetti, Andre, Miller, Paul E., Page, Guy, Mervaala, Eero, Nagy, Norbert, Kohajda, Zsófia, Jost, Norbert, Virág, László, Varró, András, Papp, Julius Gy.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707092/
https://ncbi.nlm.nih.gov/pubmed/32959887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15257
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados