The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments

BACKGROUND: In this study the effects of a new, highly selective sodium-calcium exchanger (NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca(2+) transients, cell shortening and in experimental arrhythmias. The level of selectivity of the novel inhibitor on several major transmem...

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Publicat a:PLoS One
Autors principals: Kohajda, Zsófia, Farkas-Morvay, Nikolett, Jost, Norbert, Nagy, Norbert, Geramipour, Amir, Horváth, András, Varga, Richárd S., Hornyik, Tibor, Corici, Claudia, Acsai, Károly, Horváth, Balázs, Prorok, János, Ördög, Balázs, Déri, Szilvia, Tóth, Dániel, Levijoki, Jouko, Pollesello, Piero, Koskelainen, Tuula, Otsomaa, Leena, Tóth, András, Baczkó, István, Leprán, István, Nánási, Péter P., Papp, Julius Gy, Varró, András, Virág, László
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104402/
https://ncbi.nlm.nih.gov/pubmed/27832106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166041
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