The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments

BACKGROUND: In this study the effects of a new, highly selective sodium-calcium exchanger (NCX) inhibitor, ORM-10962 were investigated on cardiac NCX current, Ca(2+) transients, cell shortening and in experimental arrhythmias. The level of selectivity of the novel inhibitor on several major transmem...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kohajda, Zsófia, Farkas-Morvay, Nikolett, Jost, Norbert, Nagy, Norbert, Geramipour, Amir, Horváth, András, Varga, Richárd S., Hornyik, Tibor, Corici, Claudia, Acsai, Károly, Horváth, Balázs, Prorok, János, Ördög, Balázs, Déri, Szilvia, Tóth, Dániel, Levijoki, Jouko, Pollesello, Piero, Koskelainen, Tuula, Otsomaa, Leena, Tóth, András, Baczkó, István, Leprán, István, Nánási, Péter P., Papp, Julius Gy, Varró, András, Virág, László
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104402/
https://ncbi.nlm.nih.gov/pubmed/27832106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166041
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