Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

Increasing evidence suggests that stem-like cells mediate cancer therapy resistance and metastasis. Breast tumour-initiating stem cells (T-ISC) are known to be enriched in CD44(+)CD24(neg/low) cells. Here, we identify two T-ISC subsets within this population in triple negative breast cancer (TNBC) l...

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Bibliographische Detailangaben
Hauptverfasser: Azzam, Diana J, Zhao, Dekuang, Sun, Jun, Minn, Andy J, Ranganathan, Prathibha, Drews-Elger, Katherine, Han, Xiaoqing, Picon-Ruiz, Manuel, Gilbert, Candace A, Wander, Seth A, Capobianco, Anthony J, El-Ashry, Dorraya, Slingerland, Joyce M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2013
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799576/
https://ncbi.nlm.nih.gov/pubmed/23982961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201302558
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