Many disease-associated variants of hTERT retain high telomerase enzymatic activity

Mutations in the gene for telomerase reverse transcriptase (hTERT) are associated with diseases including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis and cancer. Understanding the molecular basis of these telomerase-associated diseases requires dependable quantitative measurements of...

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Hlavní autoři: Zaug, Arthur J., Crary, Sharon M., Jesse Fioravanti, Matthew, Campbell, Kristina, Cech, Thomas R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799428/
https://ncbi.nlm.nih.gov/pubmed/23901009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt653
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