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Structural insights into proteoglycan-shaped Hedgehog signaling
Hedgehog (Hh) morphogens play fundamental roles during embryogenesis and adulthood, in health and disease. Multiple cell surface receptors regulate the Hh signaling pathway. Among these, the glycosaminoglycan (GAG) chains of proteoglycans shape Hh gradients and signal transduction. We have determine...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3799379/ https://ncbi.nlm.nih.gov/pubmed/24062467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310097110 |
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