Therapeutic enhancement of S-1 with CPT-11 through down-regulation of thymidylate synthase in bladder cancer

Thymidylate synthase (TS), a target enzyme of 5-fluorouracil (5-FU), is significantly associated with prognosis in various cancers. Recently, it has been reported that S-1, a novel 5-FU-based agent has an effect on bladder cancer. However, in cells with high TS level, S-1 did not have significant ef...

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Detalles Bibliográficos
Main Authors: Ide, Hiroki, Kikuchi, Eiji, Hasegawa, Masanori, Hattori, Seiya, Yasumizu, Yota, Miyajima, Akira, Oya, Mototsugu
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2013
Assuntos:
Clinical Cancer Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3799283/
https://ncbi.nlm.nih.gov/pubmed/24156021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.95
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