Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma

BACKGROUND: Recently, S-1, a novel 5-fluorouracil (5-FU)-based agent containing the strong dihydropyrimidine dehydrogenase (DPD) inhibitor, 5-chloro-2,4-dihydropyrimidine (CDHP) has been clinically used to treat various non-urothelial carcinomas (UC). High levels of thymidylate synthase (TS), the ta...

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Detalhes bibliográficos
Main Authors: Ide, Hiroki, Kikuchi, Eiji, Hasegawa, Masanori, Kozakai, Norihide, Kosaka, Takeo, Miyajima, Akira, Oya, Mototsugu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522564/
https://ncbi.nlm.nih.gov/pubmed/22998564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-420
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