MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways

BACKGROUND: MicroRNAs alter multiple cell processes and thus influence tumour carcinogenesis and progression. MiR-100 and miR-99a have been reported to be aberrantly expressed in acute leukaemia. In this study, we focused on their functions in acute lymphoblastic leukaemia (ALL) and the molecular ne...

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Main Authors: Li, X-J, Luo, X-Q, Han, B-W, Duan, F-T, Wei, P-P, Chen, Y-Q
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2013
主題:
Molecular Diagnostics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798962/
https://ncbi.nlm.nih.gov/pubmed/24030073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.562
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