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Aldosterone reprograms promoter methylation to regulate αENaC transcription in the collecting cuct

Aldosterone increases tubular Na(+) absorption largely by increasing α-epithelial Na(+) channel (αENaC) transcription in collecting duct principal cells. How aldosterone reprograms basal αENaC transcription to high-level activity in the collecting duct is incompletely understood. Promoter methylatio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yu, Zhiyuan, Kong, Qun, Kone, Bruce C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798741/
https://ncbi.nlm.nih.gov/pubmed/23926181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00407.2013
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