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Sp1 trans-activates and is required for maximal aldosterone induction of the αENaC gene in collecting duct cells

The epithelial Na(+) channel (ENaC) in the distal nephron constitutes the rate-limiting step for renal sodium reabsorption. Aldosterone increases tubular sodium absorption in large part by increasing αENaC transcription in collecting duct principal cells. We previously reported that Af9 binds to +78...

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Detaylı Bibliyografya
Asıl Yazarlar: Yu, Zhiyuan, Kong, Qun, Kone, Bruce C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761204/
https://ncbi.nlm.nih.gov/pubmed/23804453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00177.2013
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