Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice

Emerging evidence has demonstrated that saturated fatty acids prime pro-IL-1β production and inflammasome-mediated IL-1β activation is critical in obesity-associated insulin resistance (IR). Nonetheless, IL-1 receptor I-deficient (IL-1RI(−/−)) mice develop mature-onset obesity despite consuming a lo...

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Hlavní autoři: McGillicuddy, Fiona C., Reynolds, Clare M., Finucane, Orla, Coleman, Eilish, Harford, Karen A., Grant, Christine, Sergi, Domenico, Williams, Lynda M., Mills, Kingston H. G., Roche, Helen M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798700/
https://ncbi.nlm.nih.gov/pubmed/23921145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00297.2013
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