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AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5

There is a global epidemic of obesity, and obesity is known to inhibit AMP-activated protein kinase (AMPK) activity and impairs myogenesis. Myogenin mediates the fusion of myoblasts into myotubes, a critical step in myogenesis. We observed that inhibition of AMPKα1 downregulates myogenin expression...

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Bibliografiske detaljer
Main Authors: Fu, Xing, Zhao, Jun-Xing, Liang, Junfang, Zhu, Mei-Jun, Foretz, Marc, Viollet, Benoit, Du, Min
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798682/
https://ncbi.nlm.nih.gov/pubmed/23926128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00124.2013
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