Transforming Growth Factor-β (TGF-β)-mediated Connective Tissue Growth Factor (CTGF) Expression in Hepatic Stellate Cells Requires Stat3 Signaling Activation

In fibrotic liver, connective tissue growth factor (CTGF) is constantly expressed in activated hepatic stellate cells (HSCs) and acts downstream of TGF-β to modulate extracellular matrix production. Distinct from other cell types in which Smad signaling plays major role in regulating CTGF production...

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Autores principales: Liu, Yan, Liu, Heng, Meyer, Christoph, Li, Jun, Nadalin, Silvio, Königsrainer, Alfred, Weng, Honglei, Dooley, Steven, ten Dijke, Peter
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798541/
https://ncbi.nlm.nih.gov/pubmed/24005672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.478685
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