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The Thiamine Biosynthetic Enzyme ThiC Catalyzes Multiple Turnovers and Is Inhibited by S-Adenosylmethionine (AdoMet) Metabolites

ThiC (4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase; EC 4.1.99.17) is a radical S-adenosylmethionine (AdoMet) enzyme that uses a [4Fe-4S](+) cluster to reductively cleave AdoMet to methionine and a 5′-deoxyadenosyl radical that initiates catalysis. In plants and bacteria, ThiC conver...

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書目詳細資料
Main Authors: Palmer, Lauren D., Downs, Diana M.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798539/
https://ncbi.nlm.nih.gov/pubmed/24014032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.500280
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