miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best clinical approach for treatment is based on administration of temozolomide (TMZ) in combination with radiotherapy. Much evidence suggests that the intracellular level of the alkylating enzyme O(6)-methylguanin...

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Detalhes bibliográficos
Main Authors: Quintavalle, Cristina, Mangani, Davide, Roscigno, Giuseppina, Romano, Giulia, Diaz-Lagares, Angel, Iaboni, Margherita, Donnarumma, Elvira, Fiore, Danilo, De Marinis, Pasqualino, Soini, Ylermi, Esteller, Manel, Condorelli, Gerolama
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798259/
https://ncbi.nlm.nih.gov/pubmed/24147153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074466
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