miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

Glioblastoma multiforme (GBM) is one of the most deadly types of cancer. To date, the best clinical approach for treatment is based on administration of temozolomide (TMZ) in combination with radiotherapy. Much evidence suggests that the intracellular level of the alkylating enzyme O(6)-methylguanin...

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Bibliographische Detailangaben
Hauptverfasser: Quintavalle, Cristina, Mangani, Davide, Roscigno, Giuseppina, Romano, Giulia, Diaz-Lagares, Angel, Iaboni, Margherita, Donnarumma, Elvira, Fiore, Danilo, De Marinis, Pasqualino, Soini, Ylermi, Esteller, Manel, Condorelli, Gerolama
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798259/
https://ncbi.nlm.nih.gov/pubmed/24147153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074466
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