Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset

The switch from activation of the anaphase-promoting complex/cyclosome (APC/C) by CDC20 to CDH1 during anaphase is crucial for accurate mitosis. APC/C(CDC20) ubiquitinates a limited set of substrates for subsequent degradation, including Cyclin B1 and Securin, whereas APC/C(CDH1) has a broader speci...

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Bibliographic Details
Main Authors: Listovsky, Tamar, Sale, Julian E.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2013
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798251/
https://ncbi.nlm.nih.gov/pubmed/24100295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201302060
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